Omulecki W, Damato B E, Sekundo W, Lee W R, Toczyska-Rozentryt E, Omulecka A
Department of Ophthalmology, Medical University of Lódz, Poland.
Ger J Ophthalmol. 1994 Aug;3(4-5):228-31.
A case of bilateral uveal melanoma in a 54-year-old man is described. On admission of the patient for a choroidal melanoma of the left eye, an asymptomatic ciliary-body tumour was detected in his right eye. A thorough general examination did not reveal any metastases. The left eye was enucleated and local excision of the tumour in the right eye was performed 2 months later. Histology confirmed the presence of malignant melanomas in both eyes. The tumours were of similar A/B spindle-cell type. The patient remained healthy, showing no sign of metastasis or local recurrence of melanoma 9 months after the date of diagnosis. The visual acuity in his remaining eye remained 6/6. Immunological assessment of the blood serum revealed abnormally high interleukin 1 beta (IL-1 beta) and IL-2 levels. Possible implications of these findings are discussed.
本文描述了一例54岁男性双侧葡萄膜黑色素瘤病例。患者因左眼脉络膜黑色素瘤入院时，右眼发现一个无症状的睫状体肿瘤。全面的全身检查未发现任何转移灶。左眼行眼球摘除术，2个月后右眼肿瘤行局部切除术。组织学检查证实双眼均存在恶性黑色素瘤。肿瘤均为相似的A/B梭形细胞型。诊断后9个月，患者保持健康，未出现黑色素瘤转移或局部复发迹象。其留存眼视力仍为6/6。血清免疫学评估显示白细胞介素1β（IL-1β）和IL-2水平异常升高。本文讨论了这些发现的可能意义。
