Carroll D M, Franklin R M
Retina. 1981;1(3):245-51. doi: 10.1097/00006982-198101030-00022.
We employed vitreous biopsy (needle aspiration and pars plana vitrectomy) in eight cases of patients with uveitis of unknown etiology. The results of cytological and culture analysis provided the diagnosis of disseminated histoplasmosis in one patient and ocular reticulum cell sarcoma in another patient. In six patients, no specific, treatable causative agents or conditions were identified. In two of these patients, however, various etiologic agents were ruled out, which provided a basis for excluding certain therapeutic options. Where chronic inflammatory cells were seen in the vitreous, the patients responded satisfactorily to conventional therapy; patients with acute or mixed acute and chronic inflammatory cells did less well. No complications resulted from the biopsy procedure. In cases of uveitis of unknown etiology, vitreous biopsy may provide identification of specific causative agents, as well as information useful for more precise histopathologic grouping of entities in this disease.
我们对8例病因不明的葡萄膜炎患者进行了玻璃体活检（针吸活检和平部玻璃体切除术）。细胞学和培养分析结果确诊1例为播散性组织胞浆菌病，另1例为眼网状细胞肉瘤。6例患者未发现特定的、可治疗的病原体或病症。然而，在其中2例患者中，排除了各种病因，这为排除某些治疗方案提供了依据。玻璃体中可见慢性炎症细胞的患者对传统治疗反应良好；急性或急性与慢性炎症细胞混合存在的患者效果较差。活检操作未引发并发症。在病因不明的葡萄膜炎病例中，玻璃体活检可确定特定的病原体，还可为该疾病实体进行更精确的组织病理学分组提供有用信息。
