Romanski B, Kurek M, Sinkiewicz W, Swiatkowski M, Zbikowska-Gotz M
Allergol Immunopathol (Madr). 1981 Sep-Oct;9(5):411-6.
The effects of heparin, aspirin, promethazine and prednisone on late skin reactions, provoked by tobacco extracts were studied in four groups of 17 patients with coronary artery disease. In all patients, intracutaneous tests were made with four different tobacco preparations, both on the first day of their hospitalisation and after 14 days of therapy. It was found that strongly positive late skin reactions with tobacco extracts were decreased or suppressed in patients taking heparin and in patients taking prednisone, but not in those who were treated with promethazine or with aspirin. This seems to confirm the hypothesis that these reactions are really provoked by a local type III allergy to tobacco antigens.
在四组每组17例冠心病患者中，研究了肝素、阿司匹林、异丙嗪和泼尼松对烟草提取物引发的迟发性皮肤反应的影响。对所有患者在住院第一天及治疗14天后，均用四种不同的烟草制剂进行皮内试验。结果发现，服用肝素的患者和服用泼尼松的患者中，烟草提取物引发的强阳性迟发性皮肤反应有所减轻或受到抑制，但服用异丙嗪或阿司匹林的患者则未出现这种情况。这似乎证实了这样一种假说，即这些反应确实是由对烟草抗原的局部III型过敏引起的。
