Nawaz M
J Vet Pharmacol Ther. 1981 Jun;4(2):157-63. doi: 10.1111/j.1365-2885.1981.tb00725.x.
Pharmacokinetic parameters which describe the distribution and elimination of chlorpromazine in goats were determined. Following the intravenous administration of a single dose (2.5 mg/kg), disposition of the drug was described in terms of the biexponential expression Cp = Ae-alpha t + Be-beta t. Based on total (free and bound) chlorpromazine levels in plasma, pseudo-distribution equilibrium was rapidly attained, and the elimination half-life was 1.51 +/- 0.48 h (mean +/- SD, n = 8). Total body clearance, which is the sum of all clearance processes, was 80 +/- 25 ml/min/kg. The curves of an animal representative of the group, based on individual rate constants associated with the two-compartment open model, showed that at 5 h after drug administration 8% and 6% of the dose were present in the peripheral and central compartments, respectively. The kinetic parameters of chlorpromazine determined at a dosage level of 10 mg/kg body weight in six goats showed that the drug followed first-order kinetics and kinetic parameters were similar after both dose levels. Based on these findings and therapeutic plasma levels, a satisfactory intravenous regimen should be 2.0-3.5 mg/kg and the drug action will persist for 5-6 h.
测定了描述氯丙嗪在山羊体内分布和消除的药代动力学参数。静脉注射单剂量（2.5mg/kg）后，药物的处置情况用双指数表达式Cp = Ae-αt + Be-βt来描述。根据血浆中总（游离和结合）氯丙嗪水平，快速达到假分布平衡，消除半衰期为1.51±0.48小时（平均值±标准差，n = 8）。总体清除率是所有清除过程的总和，为80±25ml/min/kg。根据与二室开放模型相关的个体速率常数，该组中一只代表性动物的曲线显示，给药后5小时，剂量的8%和6%分别存在于外周室和中央室。在六只山羊中以10mg/kg体重的剂量水平测定的氯丙嗪动力学参数表明，该药物遵循一级动力学，两种剂量水平后的动力学参数相似。基于这些发现和治疗性血浆水平，满意的静脉给药方案应为2.0 - 3.5mg/kg，药物作用将持续5 - 6小时。
