Varma K J, Paul B S, Powers T E, Powers J D
J Vet Pharmacol Ther. 1981 Dec;4(4):305-9. doi: 10.1111/j.1365-2885.1981.tb00867.x.
Glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) in buffalo species (Bubalus bubalis) were estimated using a single injection technique. The total body clearances of inulin and para-aminohippuric acid (PAH) served as estimates of GFR and ERPF, respectively. Inulin and PAH were administered to animals as a single i.v. bolus. The time-concentration curves were determined for each compound. Three mathematical models were applied to the data. The two compartment model gave the best fit to the data. The single compartment model gave slightly higher values, but could be used in clinical and certain research situations to estimate renal functions when it is not practical to take large number of samples.
采用单次注射技术估算了水牛（Bubalus bubalis）的肾小球滤过率（GFR）和有效肾血浆流量（ERPF）。菊粉和对氨基马尿酸（PAH）的全身清除率分别作为GFR和ERPF的估算指标。将菊粉和PAH作为单次静脉推注给予动物。测定了每种化合物的时间-浓度曲线。对数据应用了三种数学模型。二室模型对数据的拟合效果最佳。单室模型得出的值略高，但在无法采集大量样本的情况下，可用于临床和某些研究情形中估算肾功能。
