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Anesthetics and electroconvulsive therapy seizure duration: implications for therapy from a rat model.

作者信息

Lunn R J, Savageau M M, Beatty W W, Gerst J W, Staton R D, Brumback R A

出版信息

Biol Psychiatry. 1981 Dec;16(12):1163-75.

PMID:7349626
Abstract

The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT). Compared to unanesthetized control animals, methohexital anesthesia shortened seizure duration by 42%, ketamine anesthesia tended to increase seizure duration, and Innovar anesthesia had no effect on duration of seizures.

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