Bundy K J, Butler M F, Hochman R F
J Biomed Mater Res. 1980 Sep;14(5):653-63. doi: 10.1002/jbm.820140511.
The effect of 16 pure metals on the in vitro growth of a form of dental caries producing Streptococcus mutans was studied under both aerobic and anaerobic conditions. Cobalt and copper were consistently observed to be inhibitory. With less consistency nickel, titanium, iron, and vanadium also exhibited ability to inhibit growth of the organism. Bacteriostasis apparently is contingent upon the presence of a corrosion process. The bacteriostatic agent is of uncertain identity and could be a corrosion product or a process secondary to the occurrence of corrosion. Concentrations of metals after 6 days of electrochemical dissolution in the growth medium were measured via electron microprobe analysis and compared with the amount of inhibition which resulted. Threshold concentrations above which growth did not occur were identified. As measured by threshold concentrations, wide variability between metals exists in the ability to inhibit the growth, with cobalt being particularly effective at small concentrations. This implies a sensitivity on the part of the organism that is different for different metals. The threshold concentration varied between aerobic and anaerobic conditions. Streptococcus mutans appeared more resistant to the effects of the metals under anaerobic conditions even though little difference in the amount of corrosion was detected.
研究了16种纯金属在需氧和厌氧条件下对一种致龋变形链球菌体外生长的影响。始终观察到钴和铜具有抑制作用。镍、钛、铁和钒的抑制作用不太一致，但也表现出抑制该生物体生长的能力。抑菌作用显然取决于腐蚀过程的存在。抑菌剂的成分尚不确定，可能是一种腐蚀产物或腐蚀发生后的一个次要过程。通过电子微探针分析测量了生长培养基中电化学溶解6天后金属的浓度，并将其与产生的抑制量进行比较。确定了生长未发生的阈值浓度。以阈值浓度衡量，不同金属抑制生长的能力存在很大差异，钴在低浓度下尤为有效。这意味着该生物体对不同金属的敏感性不同。需氧和厌氧条件下阈值浓度有所不同。尽管检测到的腐蚀量差异不大，但变形链球菌在厌氧条件下似乎对金属的影响更具抗性。
