Pevzner L, Balashova E K, Kruglova E E, Rozengart V I, Sherstobitov O E
Vopr Med Khim. 1978 Nov-Dec;24(6):758-62.
Content of organophosphorous inhibitors (with the structure RO/CH3/P/O/SC2H4SC2H5) of cholinesterase as well as their hydrophobic properties (distribution coefficient in hexan/water system) were studied in subcellular fractions of rat brain. Relative content of organophosphorous inhibitors was distinctly decreased in supermicrosomal fraction with increase of hydrophobic properties of the fraction. Nuclear and mitochondrial fractions contained the more hydrophobic substances in relatively higher amount. When homogenate of supermicrosomal fraction was incubated at 37 degrees, own brain cholinesterase was not depressed by organophosphorous inhibitors, containing in the fraction at low concentration. The phenomenon exhibits that content of free organophosphorous inhibitors is distinctly lower in the subcellular fractions studied than amount of the inhibitors, extracted with chloroform.
在大鼠脑亚细胞组分中研究了胆碱酯酶的有机磷抑制剂（结构为RO/CH3/P/O/SC2H4SC2H5）的含量及其疏水性质（己烷/水体系中的分配系数）。随着亚细胞组分疏水性质的增加，超微粒体组分中有机磷抑制剂的相对含量明显降低。细胞核和线粒体组分中含有相对较多的疏水性物质。当超微粒体组分匀浆在37℃孵育时，低浓度存在于该组分中的有机磷抑制剂不会抑制脑内自身的胆碱酯酶。该现象表明，在所研究的亚细胞组分中，游离有机磷抑制剂的含量明显低于用氯仿提取的抑制剂的量。
