[Inhibition of cholinesterase activity in the brain of rats by phosphoorganic inhibitors with different degrees of hydrophobia].

The activity of cholinesterase in different areas of the rat brain was studied as affected by two organophosphophorous inhibitors of the enzyme from the group of O-alkyl-S-hexylthiophosphonates, GA-89 and GA-95. Hydrophobity of GA-95 is two order higher than that of GA-89. Under the effect of GA-89 inhibition of cholinesterase in the brain is considerably higher than in blood, under the effect of GA-95 an inverse relation is observed. When both compounds are administered, the activity of cholinesterase in the cerebral cortex is most inhibited.