LaVoie E J, Rivenson A, Bedenko V, Kolb E, Ohmori T, Hoffmann D
Cancer Detect Prev. 1981;4(1-4):79-84.
Several N-nitrosamines are formed during the nitrosation of the polyamines, spermidine and spermine. Since these polyamines may represent a source for the endogenous or exogenous formation of N-nitrosamines, their major nitrosation products were assayed for carcinogenicity in male Syrian golden hamsters. Administration of N-nitroso-3-butenyl(2-propenyl)amine SC once a week for life at a dose of 300 mg/kg induced neoplasms mostly in the upper respiratory tract (nasal cavity, larynx, trachea). Lung microlithiasis (alveolar and bronchial) also developed in all these animals. In contrast, N-nitroso-3-butenyl(3-hydroxypropyl)amine and N-nitroso-4-hydroxybutyl(2-propenyl)amine induced neoplasms, primarily in the digestive tract, including the nonglandular stomach, cecum, colon, and adrenal gland.
在多胺（亚精胺和精胺）的亚硝化过程中会形成几种N-亚硝胺。由于这些多胺可能是内源性或外源性N-亚硝胺形成的一个来源，因此对它们的主要亚硝化产物进行了雄性叙利亚金仓鼠致癌性检测。每周一次以300mg/kg的剂量皮下注射N-亚硝基-3-丁烯基（2-丙烯基）胺，终生给药，主要在上呼吸道（鼻腔、喉、气管）诱发肿瘤。所有这些动物还出现了肺微石症（肺泡和支气管）。相比之下，N-亚硝基-3-丁烯基（3-羟丙基）胺和N-亚硝基-4-羟丁基（2-丙烯基）胺主要在消化道诱发肿瘤，包括非腺胃、盲肠、结肠和肾上腺。
