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Characterization of the insulin receptor and insulin-degrading activity from human lymphocytes by quantitative polyacrylamide gel electrophoresis.

作者信息

Lang U, Kahn C R, Chrambach A

出版信息

Endocrinology. 1980 Jan;106(1):40-9. doi: 10.1210/endo-106-1-40.

DOI:10.1210/endo-106-1-40
PMID:7349970
Abstract
摘要

相似文献

1
Characterization of the insulin receptor and insulin-degrading activity from human lymphocytes by quantitative polyacrylamide gel electrophoresis.通过定量聚丙烯酰胺凝胶电泳对人淋巴细胞中的胰岛素受体和胰岛素降解活性进行表征。
Endocrinology. 1980 Jan;106(1):40-9. doi: 10.1210/endo-106-1-40.
2
A possible role for insulin-receptor subunit in degrading receptor-bound insulin.
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3
Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding.培养的人淋巴母细胞IM-9胰岛素受体的结构。有证据表明胰岛素结合需要两个亚基。
J Biol Chem. 1982 Jan 25;257(2):894-8.
4
Cyclic AMP increases the concentration of insulin receptors in cultured fibroblasts and lymphocytes.环磷酸腺苷可提高培养的成纤维细胞和淋巴细胞中胰岛素受体的浓度。
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The effect of high-glucose condition on insulin binding to IM-9 lymphocytes.高糖条件对胰岛素与IM-9淋巴细胞结合的影响。
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6
Effects of sulfonylureas and clofibrate on insulin receptors in cultured human lymphocytes.
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Insulin receptor expression in the Burkitt lymphoma cells Daudi and Raji.胰岛素受体在伯基特淋巴瘤细胞Daudi和Raji中的表达。
Mol Endocrinol. 1989 Mar;3(3):597-602. doi: 10.1210/mend-3-3-597.
8
Insulin bound to the insulin receptor of IM-9 lymphocytes is more accessible to antiinsulin antibodies after treatment with dithiothreitol: bound insulin is deeply buried in the receptor-binding site.用二硫苏糖醇处理后，与IM-9淋巴细胞胰岛素受体结合的胰岛素更容易被抗胰岛素抗体识别：结合的胰岛素深埋于受体结合位点。
Endocrinology. 1984 Nov;115(5):1869-75. doi: 10.1210/endo-115-5-1869.
9
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation.胰岛素诱导的培养人淋巴细胞中的受体丢失是由于受体降解加速所致。
Proc Natl Acad Sci U S A. 1981 Nov;78(11):6917-21. doi: 10.1073/pnas.78.11.6917.
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An intact and functional soluble form of the insulin receptor is secreted by cultured cells.
Endocrinology. 1993 Sep;133(3):1369-76. doi: 10.1210/endo.133.3.8396017.

引用本文的文献

1
Binding and degradation of 125I-insulin in human erythrocytes. Comparative studies with hemolysate and membranes.125I标记胰岛素在人红细胞中的结合与降解：溶血产物与细胞膜的比较研究
J Endocrinol Invest. 1982 Sep-Oct;5(5):287-91. doi: 10.1007/BF03350516.
2
Insulin degrading enzyme activity and insulin binding of erythrocytes in normal subjects and Type 2 (non-insulin-dependent) diabetic patients.正常受试者和2型（非胰岛素依赖型）糖尿病患者红细胞的胰岛素降解酶活性及胰岛素结合情况。
Diabetologia. 1984 Jul;27(1):17-22. doi: 10.1007/BF00253495.
3
Insulin degradation in human erythrocytes. Effect of triton X-100 treatment on insulin-degrading activity of membranes.
人红细胞中的胰岛素降解。曲拉通X-100处理对膜胰岛素降解活性的影响。
J Endocrinol Invest. 1983 Dec;6(6):441-4. doi: 10.1007/BF03348343.
4
Separation of rabbit mammary-gland prolactin receptors by ion-exchange chromatography, h.p.l.c.-gel filtration and ultracentrifugation.通过离子交换色谱法、高效液相色谱-凝胶过滤法和超速离心法分离兔乳腺催乳素受体。
Biochem J. 1986 Aug 1;237(3):647-53. doi: 10.1042/bj2370647.