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Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding.

作者信息

Pollet R J, Kempner E S, Standaert M L, Haase B A

出版信息

J Biol Chem. 1982 Jan 25;257(2):894-8.

PMID:7033221
Abstract
摘要

相似文献

1
Structure of the insulin receptor of the cultured human lymphoblastoid cell IM-9. Evidence suggesting that two subunits are required for insulin binding.培养的人淋巴母细胞IM-9胰岛素受体的结构。有证据表明胰岛素结合需要两个亚基。
J Biol Chem. 1982 Jan 25;257(2):894-8.
2
Hydrodynamic characterization of the photoaffinity-labeled insulin receptor solubilized in Triton X-100.溶解于曲拉通X-100中的光亲和标记胰岛素受体的流体动力学特性
Biochemistry. 1981 Jul 7;20(14):4156-61. doi: 10.1021/bi00517a032.
3
Characterization of detergent-solubilized membrane proteins. Hydrodynamic and sedimentation equilibrium properties of the insulin receptor of the cultured human lymphoblastoid cell.去污剂增溶膜蛋白的特性。培养的人淋巴母细胞胰岛素受体的流体动力学和沉降平衡特性。
J Biol Chem. 1981 Dec 10;256(23):12118-26.
4
Internalization of 125I-insulin by IM-9 cultured human lymphocytes: a comparison between A14-monoiodo-pork and biosynthetic human insulin.IM-9培养的人淋巴细胞对¹²⁵I-胰岛素的内化作用：A14-单碘猪胰岛素与生物合成人胰岛素的比较
Diabetes Care. 1981 Mar-Apr;4(2):220-2. doi: 10.2337/diacare.4.2.220.
5
The binding of 125I-insulin to specific receptors in IM-9 human lymphocytes. Detection of radioactivity covalently linked to receptors.125I标记胰岛素与IM-9人淋巴细胞中特异性受体的结合。检测与受体共价连接的放射性。
J Biol Chem. 1981 May 25;256(10):4924-8.
6
A possible role for insulin-receptor subunit in degrading receptor-bound insulin.
Horm Metab Res. 1984 Jun;16(6):319-20. doi: 10.1055/s-2007-1014778.
7
Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes.胰岛素受体的生物合成标记：对培养的人IM-9淋巴细胞中亚基的研究。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1052-6. doi: 10.1073/pnas.78.2.1052.
8
Characterization of the insulin receptor and insulin-degrading activity from human lymphocytes by quantitative polyacrylamide gel electrophoresis.通过定量聚丙烯酰胺凝胶电泳对人淋巴细胞中的胰岛素受体和胰岛素降解活性进行表征。
Endocrinology. 1980 Jan;106(1):40-9. doi: 10.1210/endo-106-1-40.
9
Binding and degradation of semisynthetic tritiated insulin by IM-9 cultured human lymphocytes.
Diabetes. 1980 Sep;29(9):730-5. doi: 10.2337/diab.29.9.730.
10
Characterization of the human insulin receptor solubilized from cultured fibroblast and erythrocyte cell membrane preparations.
J Clin Endocrinol Metab. 1981 Jan;52(1):17-22. doi: 10.1210/jcem-52-1-17.

引用本文的文献

1
High affinity binding sites for proinsulin in human IM-9 lymphoblasts.人IM-9淋巴母细胞中胰岛素原的高亲和力结合位点。
Diabetologia. 1996 Apr;39(4):421-32. doi: 10.1007/BF00400673.
2
Elucidation of the quaternary structure of the insulin receptor.胰岛素受体四级结构的解析。
Biochem J. 1983 Apr 15;212(1):79-84. doi: 10.1042/bj2120079.
3
Studies of liver insulin receptors in non-obese and obese human subjects.非肥胖和肥胖人类受试者肝脏胰岛素受体的研究。
J Clin Invest. 1983 Nov;72(5):1729-36. doi: 10.1172/JCI111132.
4
Partial disruption of naturally occurring groups of insulin receptors on adipocyte plasma membranes by dithiothreitol and N-ethylmaleimide: the role of disulfide bonds.二硫苏糖醇和N-乙基马来酰亚胺对脂肪细胞质膜上天然存在的胰岛素受体基团的部分破坏：二硫键的作用
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1023-7. doi: 10.1073/pnas.80.4.1023.
5
Pathogenetic mechanisms of hereditary diabetes mellitus.遗传性糖尿病的发病机制。
Hum Genet. 1983;63(2):100-6. doi: 10.1007/BF00291526.
6
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.针对人胰岛素受体的单克隆抗体可阻断胰岛素结合并抑制胰岛素作用。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7312-6. doi: 10.1073/pnas.79.23.7312.
7
Evidence for dimer structure of proton-pumping cytochrome c oxidase, an analysis by radiation inactivation.质子泵细胞色素c氧化酶二聚体结构的证据：辐射失活分析
EMBO J. 1986 Jul;5(7):1515-9. doi: 10.1002/j.1460-2075.1986.tb04391.x.
8
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor.胰岛素受体的单体αβ形式比完整的α2β2形式表现出更高的胰岛素依赖性酪氨酸特异性蛋白激酶活性。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6095-9. doi: 10.1073/pnas.82.18.6095.