抗坏血酸对中性粒细胞运动的影响。

Effects of ascorbic acid on neutrophil locomotion.

作者信息

Dallegri F, Lanzi G, Patrone F

出版信息

Int Arch Allergy Appl Immunol. 1980;61(1):40-5. doi: 10.1159/000232413.

Abstract

The effects of ascorbic acid on neutrophil locomotion were studied in experimental conditions able to dissociate random from truly directional motility. It was shown that the significant enhancement of chemotaxis achievable with high ascorbic acid concentrations was due to an increase of the true chemotactic response. With lower concentrations of ascorbic acid, chemotactic values were unaffected as the result of an increase in the rate of neutrophil locomotion with a concomitant inhibition of the true chemotactic response. Ascorbic acid appeared to exert its effect on the whole moving cell population.

摘要

在能够区分随机运动与真正定向运动的实验条件下，研究了抗坏血酸对中性粒细胞运动的影响。结果表明，高浓度抗坏血酸可显著增强趋化作用，这是由于真正的趋化反应增强所致。当抗坏血酸浓度较低时，趋化值未受影响，这是因为中性粒细胞运动速率增加，同时真正的趋化反应受到抑制。抗坏血酸似乎对整个运动细胞群体都有作用。