Patrone F, Dallegri F, Lanzi G, Sacchetti C
Int Arch Allergy Appl Immunol. 1981;64(3):259-65. doi: 10.1159/000232702.
The effects of the sulphydryl group donor N-(2-mercaptopropionyl) glycine on neutrophil locomotion were evaluated in vitro. The drug, when used at a concentration of 10(-3) M was found to stimulate the random migration and chemotaxis of normal neutrophils as a result of an enhanced rate of locomotion. The true chemotactic response was unaffected. N-(2-mercaptopropionyl) glycine appeared to exert its effect on the whole moving cell population.
在体外评估了巯基供体N-(2-巯基丙酰基)甘氨酸对中性粒细胞运动的影响。发现该药物在浓度为10^(-3) M时,由于运动速率提高,可刺激正常中性粒细胞的随机迁移和趋化性。真正的趋化反应未受影响。N-(2-巯基丙酰基)甘氨酸似乎对整个移动的细胞群体产生作用。