Patrone F, Dallegri F, Lanzi G, Sacchetti C
Br J Exp Pathol. 1980 Oct;61(5):486-9.
The locomotion of human neutrophils deactivated by pretreatment with appropriate concentration of chemoattractant was investigated in experimental conditions capable of dissociating random from truly directional motility. It was shown that deactivated neutrophils lose true chemotactic responsiveness, being unaffected by the rate of locomotion. Ascorbic acid, when present in appropriate concentrations during the deactivation step, completely prevented the loss of true chemotactic responsiveness by cells--that is, their chemotactic deactivation.
在能够区分随机运动和真正定向运动的实验条件下，研究了用适当浓度趋化因子预处理后失活的人类中性粒细胞的运动。结果表明，失活的中性粒细胞失去了真正的趋化反应性，但其运动速率不受影响。在失活步骤中，当存在适当浓度的抗坏血酸时，可完全防止细胞失去真正的趋化反应性，即防止其趋化失活。
