抗坏血酸对中性粒细胞趋化失活的预防作用。

Prevention of neutrophil chemotactic deactivation by ascorbic acid.

作者信息

Patrone F, Dallegri F, Lanzi G, Sacchetti C

出版信息

Br J Exp Pathol. 1980 Oct;61(5):486-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2041532/

Abstract

The locomotion of human neutrophils deactivated by pretreatment with appropriate concentration of chemoattractant was investigated in experimental conditions capable of dissociating random from truly directional motility. It was shown that deactivated neutrophils lose true chemotactic responsiveness, being unaffected by the rate of locomotion. Ascorbic acid, when present in appropriate concentrations during the deactivation step, completely prevented the loss of true chemotactic responsiveness by cells--that is, their chemotactic deactivation.

摘要

在能够区分随机运动和真正定向运动的实验条件下，研究了用适当浓度趋化因子预处理后失活的人类中性粒细胞的运动。结果表明，失活的中性粒细胞失去了真正的趋化反应性，但其运动速率不受影响。在失活步骤中，当存在适当浓度的抗坏血酸时，可完全防止细胞失去真正的趋化反应性，即防止其趋化失活。

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Br J Dermatol. 1980 Jan;102(1):49-56. doi: 10.1111/j.1365-2133.1980.tb05671.x.

2

Effects of ascorbic acid on neutrophil locomotion.抗坏血酸对中性粒细胞运动的影响。

Int Arch Allergy Appl Immunol. 1980;61(1):40-5. doi: 10.1159/000232413.

3

The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase.趋化因子对兔中性粒细胞的失活作用及可激活酯酶的性质。

J Exp Med. 1968 Apr 1;127(4):693-709. doi: 10.1084/jem.127.4.693.

4

Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.白细胞移动与趋化性。评估及证明一种细胞源性趋化因子的新方法。

J Exp Med. 1973 Feb 1;137(2):387-410. doi: 10.1084/jem.137.2.387.

5

Ascorbic acid levels in phagocytic cells.吞噬细胞中的抗坏血酸水平。

Proc Soc Exp Biol Med. 1974 Apr;145(4):1170-3. doi: 10.3181/00379727-145-37974.

6

Distinct chemokinetic and chemotactic responses in neutrophil granulocytes.中性粒细胞中不同的化学动力学和趋化反应。

Eur J Immunol. 1978 Jan;8(1):1-7. doi: 10.1002/eji.1830080102.

7

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8

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