Rice M C, O'Brien S J
Nature. 1980 Jan 10;283(5743):157-61. doi: 10.1038/283157a0.
The extent of allelic variation has been estimated at 46 structural gene loci within three major colonies of Swiss mice and between inbred derivative strains. The colonies have retained nearly the same amount and type of variation found in natural murine or human populations despite laboratory propagation for more than 50 years (175 generations). The population genetic structures of the Swiss mouse colonies were comparable to an island population in which random fixation, and not inbreeding or population bottlenecks, is apparently responsible for slight losses in genetic variance.
在瑞士小鼠的三个主要群体内部以及近交衍生品系之间，已对46个结构基因座的等位基因变异程度进行了估计。尽管经过了50多年（175代）的实验室繁殖，但这些群体仍保留了在自然鼠类或人类群体中发现的几乎相同数量和类型的变异。瑞士小鼠群体的群体遗传结构与岛屿群体相当，在岛屿群体中，随机固定而非近亲繁殖或群体瓶颈显然是造成遗传方差略有损失的原因。
