Cunningham E E, Brentjens J R, Zielezny M A, Andres G A, Venuto R C
Am J Med. 1980 Jan;68(1):47-53. doi: 10.1016/0002-9343(80)90164-3.
The existence of a nephropathy secondary to intravenous narcotic use remains a matter of debate. To determine whether heroin use and renal disease are associated, a clinicopathologic and epidemiologic study was undertaken in the Buffalo Standard Metropolitan Statistical Area (Buffalo-SMSA). Over the past 10 years, 23 addicts presented with the nephrotic syndrome and/or renal insufficiency. All patients were black men 18 to 45 years of age. Kidney biopsies performed on 21 patients uniformly showed sclerosing glomerulonephritis. End stage renal disease (ESRD) developd in 15 of these patients. In the epidemiologic evaluation which spanned four and a half years, heroin use was highly correlated with both sclerosing glomerulonephritis and ESRD. A history of intravenous heroin use was found in 26 per cent of the new cases of sclerosing glomerulonephritis and in 13 per cent of the new cases of ESRD in patients aged 18 to 45 years (p less than 0.000001). This investigation confirms the existence of heroin-associated sclerosing glomerulonephritis in black men. Heroin use appears to be a major risk factor for ESRD in the Buffalo-SMSA.
静脉注射麻醉品继发肾病的存在仍存在争议。为了确定海洛因使用与肾脏疾病是否相关，在布法罗标准大都市统计区（布法罗 - SMSA）进行了一项临床病理和流行病学研究。在过去10年中，23名成瘾者出现肾病综合征和/或肾功能不全。所有患者均为18至45岁的黑人男性。对21名患者进行的肾活检均显示硬化性肾小球肾炎。其中15名患者发展为终末期肾病（ESRD）。在为期四年半的流行病学评估中，海洛因使用与硬化性肾小球肾炎和ESRD均高度相关。在18至45岁的硬化性肾小球肾炎新病例中，26%有静脉注射海洛因史，在ESRD新病例中，13%有静脉注射海洛因史（p小于0.000001）。这项调查证实了黑人男性中存在海洛因相关的硬化性肾小球肾炎。在布法罗 - SMSA，海洛因使用似乎是ESRD的主要危险因素。
