Lupinetti M, Mehigan D, Cameron J L
Am J Surg. 1980 Jan;139(1):113-8. doi: 10.1016/0002-9610(80)90239-1.
The records of 202 patients with chronic ulcerative colitis seen over a 12 year period were reviewed. Over one half (55 percent) were found to have liver function test abnormalities. These abnormalities correlated with the extent and severity of ulcerative colitis but not with the duration of the disease. Eight patients (4 percent) developed cirrhosis and four required portasystemic decompression for bleeding varices. Four patients (2 percent) developed biliary tract complications. Two patients were diagnosed as having sclerosing cholangitis, and two patients developed carcinoma of the extrahepatic biliary tree. Three of these four patients had whole colon involvement, but all four had mild clinical disease. It is concluded that the hepatobiliary complications of ulcerative colitis are the most frequent and serious extracolonic manifestations of the disease.
回顾了12年间收治的202例慢性溃疡性结肠炎患者的病历。发现超过一半（55%）的患者肝功能检查异常。这些异常与溃疡性结肠炎的范围和严重程度相关，但与疾病持续时间无关。8例（4%）患者发展为肝硬化，4例因静脉曲张出血需要进行门体分流减压。4例（2%）患者出现胆道并发症。2例被诊断为硬化性胆管炎，2例发生肝外胆管癌。这4例患者中有3例全结肠受累，但4例临床症状均较轻。结论是，溃疡性结肠炎的肝胆并发症是该疾病最常见和最严重的结肠外表现。
