Rondouin G, Baldy-Moulinier M, Passouant P
Brain Res. 1980 Jan 13;181(2):413-24. doi: 10.1016/0006-8993(80)90623-x.
The effects of daily electrical stimulation of ventral hippocampus (hippocampal kingling) on the sleep-waking cycle were studied in the cat. Hippocampal kindling developed in 61 days and 4 stages according to progressive development of EEG and behavioral seizures and culminated in generalized convulsions. The 'all or none' response of Goddard was found once generalized seizures appeared. The influence of the hippocampal kindling effect on the sleep-waking cycle was investigated kindling and kindled cats. Paradoxical sleep (PS) decreased from stage 2 to stage 4. This diminution persisted even if stimulation was stopped. No significant modifications of waking (W) and slow wave sleep (SWS) occurred. A peculiar facilitation of interictal discharges by SWS was noticed. In contrast, waking and PS inhibited them. The influence of the modification of the sleep-waking cycle induced by alpha-methylparatyrosine (AMPT) known as an inhibitor of catecholamine (CA) synthesis was investigated in hippocampal kidling. Two principal results were found: (1) a PS increase during the 6 h following AMPT injection; (2) a lack or a delay of kindling in two animals which showed an increase of PS after AMPT injections. The results are discussed according to the modifications of both the sleep-waking cycle and the brain catecholamine levels secondary to AMPT treatment.
在猫身上研究了每日对腹侧海马体进行电刺激（海马体点燃）对睡眠-觉醒周期的影响。海马体点燃在61天内根据脑电图和行为性癫痫的逐步发展分为4个阶段，并最终导致全身性惊厥。一旦出现全身性癫痫发作，就会发现戈达德的“全或无”反应。对点燃和已点燃的猫研究了海马体点燃效应对睡眠-觉醒周期的影响。异相睡眠（PS）从第2阶段减少到第4阶段。即使停止刺激，这种减少仍持续存在。清醒（W）和慢波睡眠（SWS）没有明显变化。注意到慢波睡眠对发作间期放电有特殊的促进作用。相反，清醒和异相睡眠则抑制它们。研究了α-甲基对酪氨酸（AMPT）（一种儿茶酚胺（CA）合成抑制剂）诱导的睡眠-觉醒周期改变对海马体点燃的影响。发现了两个主要结果：（1）注射AMPT后6小时内异相睡眠增加；（2）两只在注射AMPT后异相睡眠增加的动物出现点燃缺失或延迟。根据AMPT治疗继发的睡眠-觉醒周期和脑儿茶酚胺水平的改变对结果进行了讨论。
