Abe M, Takahashi M, Yabumoto E, Adachi H, Yoshii M, Mori K
Cancer. 1980 Jan 1;45(1):40-8. doi: 10.1002/1097-0142(19800101)45:1<40::aid-cncr2820450108>3.0.co;2-2.
Clinical results of intraoperative radiotherapy in neoplasms of the stomach, colon, pancreas, biliary tract, bladder, prostate, lung, mediastinum and brain, and soft-tissue sarcomas are reported. After resectable lesions were removed at surgery, residual cancer nests were sterilized by irradiation before surgical closure. Since the lesion can be exposed directly to radiation and sensitive normal structures are positioned outside the treatment volume, a cancerocidal dose can be safely and precisely delivered to the cancer without affecting normal structure. The great advantage of the intraoperative electron beam therapy lies in the treatment of radioresistant tumors and lesions located near radiosensitive organs. Several patients with unresectable tumors were treated by the intraoperative technique and are alive after more than 5 years.
本文报告了术中放疗在胃、结肠、胰腺、胆道、膀胱、前列腺、肺、纵隔、脑肿瘤以及软组织肉瘤中的临床结果。手术切除可切除病变后，在手术缝合前通过照射对残留癌巢进行灭活。由于病变可直接暴露于辐射下，且敏感正常结构位于治疗体积之外，因此可以在不影响正常结构的情况下，安全、精确地将杀灭癌细胞的剂量传递至肿瘤。术中电子束治疗的一大优势在于治疗对放疗耐药的肿瘤以及位于放射敏感器官附近的病变。数例无法切除肿瘤的患者接受了术中放疗技术治疗，且存活超过5年。
