恶性类癌肿瘤中的雌激素受体蛋白：2例报告

Estrogen receptor protein in malignant carcinoid tumor: a report of 2 cases.

作者信息

Keshgegian A A, Wheeler J E

出版信息

Cancer. 1980 Jan 15;45(2):293-6. doi: 10.1002/1097-0142(19800115)45:2<293::aid-cncr2820450216>3.0.co;2-5.

DOI:10.1002/1097-0142(19800115)45:2<293::aid-cncr2820450216>3.0.co;2-5

Abstract

Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard-plot analysis of a dextran-coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high-affinity binding (Kd = 6.8 and 2.6 x 10(-10) M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non-breast or non-gynecologic neoplasms that contain the receptor. The significane of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.

摘要

通过葡聚糖包被活性炭分析法的Scatchard图分析、雌激素类似物对结合的抑制作用（67%和63%）以及高亲和力结合（Kd = 6.8和2.6×10⁻¹⁰ M）表明，两名老年女性转移性恶性类癌肿瘤病例含有大量雌激素受体（19和32飞摩尔/毫克蛋白）。恶性类癌肿瘤中雌激素受体的证实扩展了含有该受体的非乳腺或非妇科肿瘤的范围。此类肿瘤中雌激素受体的意义尚不确定；它可能代表恶性肿瘤中雌激素受体蛋白基因的异常去抑制。