恶性胰腺和胎儿胰腺中的雌激素受体蛋白
Oestrogen receptor proteins in malignant and fetal pancreas.
作者信息
Greenway B, Iqbal M J, Johnson P J, Williams R
出版信息
Br Med J (Clin Res Ed). 1981 Sep 19;283(6294):751-3. doi: 10.1136/bmj.283.6294.751.
Abstract
High levels of high-affinity oestrogen binding were detected in cytosolic and nuclear fractions of tumour tissue from six patients with pancreatic carcinoma. Similar binding was found in fetal but not in normal adult pancreas, making depression of fetal genes a possibility. Specific androgen binding was not detectable. These findings suggest that anti-oestrogen treatment may offer a new approach to the treatment of pancreatic carcinoma.
摘要
在6例胰腺癌患者肿瘤组织的胞质和核组分中检测到高水平的高亲和力雌激素结合。在胎儿胰腺中发现了类似的结合，但在正常成人胰腺中未发现，这使得胎儿基因受抑制成为可能。未检测到特异性雄激素结合。这些发现表明，抗雌激素治疗可能为胰腺癌的治疗提供一种新方法。
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