Constantopoulos A, Lagos P, Benetos S, Matsaniotis N
Dermatologica. 1980;160(2):121-4. doi: 10.1159/000250484.
Levamisole has been used to treat a patient with disseminated neonatal herpes simplex infection. The skin lesions and the convulsions disappeared completely 20 days after therapy. A trial to reduce the dose of levamisole resulted in a new episode of seizures and skin lesions. A similar relapse was observed at the age of 7 months, which resulted in control of symptoms by increasing the dose of levamisole. The patient has received levamisole for 20 months. She is now 29 months old and is doing well without levamisole, except for a slight motor deficity. If further investigations confirm the present findings, levamisole may well become a useful agent in the treatment of disseminated herpes simplex infection.
左旋咪唑已被用于治疗一名患有播散性新生儿单纯疱疹感染的患者。治疗20天后，皮肤病变和惊厥完全消失。降低左旋咪唑剂量的试验导致癫痫发作和皮肤病变再次出现。在7个月大时观察到类似的复发情况，通过增加左旋咪唑剂量使症状得到控制。该患者已接受左旋咪唑治疗20个月。她现在29个月大，停用左旋咪唑后情况良好，只是有轻微的运动功能缺陷。如果进一步的研究证实目前的发现，左旋咪唑很可能成为治疗播散性单纯疱疹感染的一种有效药物。
