犬的代偿性肾肥大：单个肾单位的肾小球滤过率
Compensatory renal hypertrophy in dogs: single nephron glomerular filtration rate.
作者信息
Carrière S
出版信息
Yale J Biol Med. 1978 May-Jun;51(3):307-13.
Kidney weight, length of superficial and juxtamedullary proximal tubules, glomerular diameter, kidney filtration rate and PAH clearance, sodium excretion and intrarenal distribution of filtration (with (14)C-ferrocyanide) were measured in the remaining hypertrophic kidneys of dogs 10 days after unilateral nephrectomy. Whereas kidney weight increased to 75 percent of the original total renal mass, proximal tubule length and mean glomerular diameter remained unchanged. PAH and creatinine clearance, and absolute, but not fractional, sodium excretion, rose significantly. The ratio superficial/juxtamedullary filtration rate remained unchanged, indicating parallel increases of filtration in both cortical regions of hypertrophied kidneys.
在单侧肾切除术后10天，对犬剩余的肥大肾脏测量肾重量、浅表和近髓质近端小管长度、肾小球直径、肾滤过率和对氨基马尿酸清除率、钠排泄以及滤过的肾内分布（用（14）C-亚铁氰化物）。肾重量增加至原来总肾质量的75%，而近端小管长度和平均肾小球直径保持不变。对氨基马尿酸和肌酐清除率以及绝对钠排泄量（而非分数钠排泄量）显著升高。浅表/近髓质滤过率的比值保持不变，表明肥大肾脏的两个皮质区域滤过均呈平行增加。
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