阿霉素增强环磷酰胺诱导的膀胱损伤。

Adriamycin enhancement of cyclophosphamide-induced bladder injury.

作者信息

Ershler W B, Gilchrist K W, Citrin D L

出版信息

J Urol. 1980 Jan;123(1):121-2. doi: 10.1016/s0022-5347(17)55813-9.

Abstract

Hemorrhagic cystitis as a complication of cancer chemotherapy has been most commonly associated with cyclophosphamide. We report on a patient who had received cyclophosphamide for treatment of breast carcinoma and had hemorrhagic cystitis temporally associated with subsequent adriamycin therapy. The development of subclinical bladder injury induced by cyclophosphamide and enhanced by adriamycin similar to their combined toxicities at other sites (skin, esophagus and heart) is postulated.

摘要

出血性膀胱炎作为癌症化疗的一种并发症，最常与环磷酰胺相关。我们报告了一名接受环磷酰胺治疗乳腺癌的患者，其出血性膀胱炎在时间上与随后的阿霉素治疗相关。推测环磷酰胺诱导并由阿霉素加重的亚临床膀胱损伤的发生，类似于它们在其他部位（皮肤、食管和心脏）的联合毒性作用。