氧化甾醇及其可能的前体的血管毒性。
Angiotoxicity of oxygenated sterols and possible precursors.
作者信息
Imai H, Werthessen N T, Subramanyam V, LeQuesne P W, Soloway A H, Kanisawa M
出版信息
Science. 1980 Feb 8;207(4431):651-3. doi: 10.1126/science.7352277.
PMID:7352277
Abstract
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.
摘要
在静脉注射氧化甾醇后的3天、7天和10天，观察了兔主动脉和肺动脉中的细胞死亡、炎症及修复情况。因此，可能是氧化甾醇而非胆固醇在动脉壁损伤和病变发展中起主要作用。
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