Danforth D N, Javadpour N, Bergman S M, Terrill R
Urology. 1980 Jan;15(1):17-22. doi: 10.1016/0090-4295(80)90532-4.
The pressure effects of urinary reflux on renal structure and function were studied using a canine model in which the kidney was autotransplanted to the iliac fossa and the urine drained through a pyelocystostomy. This provided grade III reflux of urine (distention of the renal pelvis and calyces). A control group of nonrefluxing animals with the ureter and ureterovesical valve intact was studied in an identical fashion, and all animals were observed for one year. The reflux of sterile urine was not associated with any impairment of the inulin clearance or transport maximum of para-aminohippuric acid. There were no histologic abnormalities of glomeruli, tubules, or interstitium noted in the animals exposed to sterile reflux, nor were any differences found between the study and control groups. The transmission of bladder pressures into the renal pelvis and calyces during reflux is considered an unimportant factor in explaining the renal damage noted from sterile reflux of short duration in adults. The pyelocystostomy provides a satisfactory means of urinary drainage, and may be used effectively to study the properties of urinary reflex.
利用犬模型研究了尿液反流对肾脏结构和功能的压力影响，在该模型中，将肾脏自体移植至髂窝，并通过肾盂膀胱造口术引流尿液。这导致了Ⅲ级尿液反流（肾盂和肾盏扩张）。以相同方式研究了输尿管和输尿管膀胱瓣膜完整的无反流动物对照组，所有动物均观察一年。无菌尿液反流与菊粉清除率或对氨基马尿酸最大转运量的任何损害均无关联。在暴露于无菌反流的动物中，未发现肾小球、肾小管或间质的组织学异常，研究组与对照组之间也未发现任何差异。反流期间膀胱压力向肾盂和肾盏的传递被认为是解释成人短期无菌反流所致肾损伤的一个不重要因素。肾盂膀胱造口术提供了一种令人满意的尿液引流方法，可有效地用于研究尿液反流的特性。
