Schulz G
Z Gesamte Inn Med. 1978 Nov 1;33(21):784-9.
Pulmonary fibroses which are regarded as reactive final stage of a great number of pulmonary diseases apart from their unfavourable prognosis may also therapeutically be scarcely influenced. With D-penicillamine a remedy was found which first intervened directly into the collagenic metabolism. Mechanisms of action, therapy indications and side-effects are compiled taking into consideration a broad survey of literature. Together with the casuistic description of three cases of treatment of a pulmonary fibrosis with D-penicillamine is reported on won experiences. As criterion of the therapeutic effectivity the general condition, the X-ray findings, above all, however, functional parameters of the lungs are regarded. When the pros and cons of the expenditure and the high frequency of side-effects of D-penicillamine compared with the changing therapeutic results with this medicament are considered must also thought of the fact of an otherwise not existing possibility of an effective influencibility of the pulmonary fibrosis. Actual tendencies and experiments for the improvement of the fibrose therapy are discussed.
除了预后不良外，肺纤维化被视为大量肺部疾病的反应性终末期，在治疗上也很难受到影响。发现D-青霉胺这种药物首先直接干预胶原代谢。结合广泛的文献综述，阐述了其作用机制、治疗适应症和副作用。同时报告了三例用D-青霉胺治疗肺纤维化的病例及所得经验。作为治疗有效性的标准，考虑的是一般状况、X线检查结果，然而，最重要的是肺部的功能参数。当考虑到D-青霉胺的费用、高副作用发生率与该药物变化的治疗结果的利弊时，还必须考虑到肺纤维化原本不存在有效可影响性这一事实。讨论了改善纤维化治疗的当前趋势和实验。
