Larjava H, Saarni H, Tammi M, Penttinen R, Rönnemaa T
Atherosclerosis. 1980 Feb;35(2):135-43. doi: 10.1016/0021-9150(80)90079-9.
The effect of cortisol on the synthesis of glycosaminoglycans (GAGs) was studied in cultured human aortic smooth muscle cells. Cortisol, at a level slightly exceeding the physiological concentration (10(-6) M), decreased the synthesis of hyaluronic acid (HA) by 50% but had no significant effect on the synthesis of sulphated GAGs. The ratio of HA to sulphated GAGs decreased by 47%. These effects were most marked in the fraction secreted into the culture medium. Cortisol neither affected the activity of the hyaluronic acid synthesizing enzyme complex in a cell-free system nor the molecular weight distribution of hyaluronic acid. We suggest that the atherogenity of cortisol and stress may be associated with their effect on the synthesis of HA by the smooth muscle cells of the arterial wall.
在培养的人主动脉平滑肌细胞中研究了皮质醇对糖胺聚糖（GAGs）合成的影响。皮质醇水平略高于生理浓度（10⁻⁶ M）时，可使透明质酸（HA）的合成减少50%，但对硫酸化GAGs的合成无显著影响。HA与硫酸化GAGs的比例下降了47%。这些影响在分泌到培养基中的部分最为明显。皮质醇既不影响无细胞系统中透明质酸合成酶复合物的活性，也不影响透明质酸的分子量分布。我们认为，皮质醇和应激的致动脉粥样硬化性可能与其对动脉壁平滑肌细胞HA合成的影响有关。
