Feld R D, van Steirteghem A C, Zweig M H, Weimar G W, Narayana A S, Witte D L
Clin Chim Acta. 1980 Jan 31;100(3):267-73. doi: 10.1016/0009-8981(80)90276-4.
Creatine kinase BB isoenzyme (CK-BB) was detected in abnormal amounts in serum samples from 11 of 46 patients with Stage D carcinoma of the prostate by electrophoresis. Thirteen of 46 Stage D patients had elevated acid phosphatase values and 10 of these 13 had elevated CK-BB. CK-BB elevations were less frequent in earlier stages of prostatic cancer; Stage C: 0 of 35, Stage B: 1 of 26, Stage A: 0 of 3 and none in a group of 35 with BPH, prostatitis and bladder cancer. Results of CK-BB by a specific radioimmunoassay correlated well with those obtained by electrophoresis in most cases. Several patients were followed over time and data on CK-BB is presented for this interval. The origin of the CK-BB is still unclear. The BB isoenzyme predominates in prostatic tissue and CK-BB is the fetal form of the enzyme in human muscle and myocardium. The increase in serum CK-BB may be related to increased release of the isoenzyme, either from the prostate itself or from a metastatic lesion, or may represent a release of the fetal form of the enzyme from dedifferentiated tumor tissue.
通过电泳检测发现，46例D期前列腺癌患者中有11例血清样本中的肌酸激酶BB同工酶（CK-BB）含量异常。46例D期患者中有13例酸性磷酸酶值升高，其中10例CK-BB升高。CK-BB升高在前列腺癌早期阶段较少见；C期：35例中0例，B期：26例中1例，A期：3例中0例，35例良性前列腺增生、前列腺炎和膀胱癌患者中无一例升高。在大多数情况下，通过特异性放射免疫测定法检测CK-BB的结果与通过电泳获得的结果相关性良好。对部分患者进行了随访，并给出了该时间段内CK-BB的数据。CK-BB的来源仍不清楚。BB同工酶在前列腺组织中占主导地位，CK-BB是人类肌肉和心肌中该酶的胎儿形式。血清CK-BB升高可能与该同工酶从前列腺本身或转移病灶中释放增加有关，或者可能代表去分化肿瘤组织中该酶胎儿形式的释放。
