El-Shribiny A, Bharvaga A, Fitzpatrick J, Murphy G P
J Surg Oncol. 1985 Mar;28(3):232-6. doi: 10.1002/jso.2930280319.
Fifty-nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK-BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK-BB as a follow-up marker compared to PAP. Thirty-three patients were in stable, 19 in progressive, and seven in regressive clinical state. CK-BB was above normal level in 52 (88%) out of 59 patients with no statistically significant difference between the three clinical states. On the other hand, PAP was above normal level in only 23 patients (38.98%) with statistically significant difference between the three clinical states (P less than 0.001). The PAP/CK-BB index was below 1 in stable and regressive condition, while it was above 1 in eight out of 19 patients with progressive disease. The PAP/CK-BB index may be of prognostic importance. CK-BB by RIA was abnormal in more cases than PAP. In this way CK-BB reflects the presence of the tumor and may be used for diagnosis; however, it does not reflect the clinical response as PAP does.
对59例接受不同治疗方式的D期前列腺癌患者，采用放射免疫分析（RIA）技术检测其血清中的肌酸磷酸激酶同工酶BB（CK-BB）和前列腺酸性磷酸酶（PAP）水平，以研究与PAP相比，CK-BB作为随访标志物的可能用途。33例患者病情稳定，19例病情进展，7例病情呈消退状态。59例患者中有52例（88%）的CK-BB高于正常水平，三种临床状态之间无统计学显著差异。另一方面，只有23例患者（38.98%）的PAP高于正常水平，三种临床状态之间存在统计学显著差异（P<0.001）。在病情稳定和消退的情况下，PAP/CK-BB指数低于1，而在19例病情进展的患者中，有8例该指数高于1。PAP/CK-BB指数可能具有预后意义。通过RIA检测，CK-BB异常的病例比PAP更多。因此，CK-BB可反映肿瘤的存在，可用于诊断；然而，它不像PAP那样能反映临床反应。
