皮下注射钙肝素和钠肝素的生物等效性。

Bioequivalence of subcutaneous calcium and sodium heparins.

作者信息

Bender F, Aronson L, Hougie C, Moser K

出版信息

Clin Pharmacol Ther. 1980 Feb;27(2):224-9. doi: 10.1038/clpt.1980.35.

DOI:10.1038/clpt.1980.35

Abstract

The bioequivalence of subcutaneous porcine calcium and sodium heparins was studied in 48 normal male subjects randomly assigned to 1 of 4 study groups. Each subject received a single subcutaneous injection of 15,000 U of calcium heparin or 1 of 3 sodium heparins. Serial coagulation studies (Lee-White clotting time, activated partial thromboplastin time, thrombin calcium clotting time, and heparin level) were performed over 10 hr. There were no significant differences in anticoagulant effect between groups.

摘要

在48名正常男性受试者中研究了皮下注射猪源钙肝素和钠肝素的生物等效性，这些受试者被随机分配到4个研究组中的1组。每名受试者接受一次皮下注射15,000 U钙肝素或3种钠肝素中的1种。在10小时内进行了一系列凝血研究（Lee-White凝血时间、活化部分凝血活酶时间、凝血酶钙凝血时间和肝素水平）。各组之间的抗凝效果没有显著差异。