Rossoff L, Zeldin R, Hew E, Aberman A
Chest. 1980 Feb;77(2):142-6. doi: 10.1378/chest.77.2.142.
The theoretic effect of increased values for the oxygen pressure at an oxygen saturation of 50 percent on oxygen delivery in arterial hypoxemia due to right-to-left shunting was analyzed using a mathematical model of the oxygen-hemoglobin equilibrium curve. We found that, regardless of the size of the shunt, a rightward shift of the curve resulted in increased mixed venous oxygen tension, increased arterial oxygen pressure, and, hence, a decreased alveolar-arterial oxygen pressure difference compared to the standard curve (hemoglobin level, cardiac output, and oxygen consumption remaining constant).
使用氧合血红蛋白平衡曲线的数学模型，分析了在右向左分流导致的动脉低氧血症中，氧饱和度为50%时氧分压升高对氧输送的理论影响。我们发现，无论分流大小如何，与标准曲线相比（血红蛋白水平、心输出量和氧消耗量保持不变），曲线右移会导致混合静脉血氧张力升高、动脉氧分压升高，从而使肺泡-动脉氧分压差降低。
