Siggaard-Andersen O, Fogh-Andersen N, Gøthgen I H, Larsen V H
Department of Anesthesiology/Intensive Care Medicine, Herlev University Hospital, Copenhagen, Denmark.
Crit Care Med. 1995 Jul;23(7):1284-93. doi: 10.1097/00003246-199507000-00020.
To describe system requirements for determination of the oxygen status of the blood using the oxygen status algorithm, a computer program. To define the oxygen extractivity, a term we propose, of the arterial blood and the oxygen extraction tension. To describe the different causes of tissue hypoxia, and the clinical interpretation of mixed venous oxygen tension and oxygen consumption rate.
Previous physiological and clinical studies related to oxygen status of the blood.
The oxygen status algorithm calculates the oxygen extraction tension and generates the oxygen graph as an aid in interpreting oxygen status of the patient. A cybernetic scheme explains the causes of tissue hypoxia and forms the basis for the interpretation of changes in the mixed venous oxygen tension. A diagram with the mixed venous oxygen tension on the abscissa and the oxygen consumption rate on the ordinate illustrates the oxygen flux dependent oxygen consumption rate. A graph shows the relationship between mixed venous oxygen tension and oxygen delivery.
The oxygen status of arterial blood comprises three groups of quantities related to arterial oxygen tension, hemoglobin oxygen capacity, and hemoglobin oxygen affinity. Disturbances in one of these groups may be compensated by opposite changes in one or both of the other. The oxygen extraction tension indicates the degree of compensation, and mixed venous oxygen tension is the key parameter in evaluating the presence of a state of oxygen flux-dependent oxidative metabolism.
描述使用氧状态算法（一种计算机程序）测定血液氧状态的系统要求。定义我们提出的动脉血氧提取率和氧提取张力这一术语。描述组织缺氧的不同原因，以及混合静脉血氧张力和氧消耗率的临床解读。
以往与血液氧状态相关的生理学和临床研究。
氧状态算法计算氧提取张力并生成氧图，以辅助解读患者的氧状态。一种控制论方案解释了组织缺氧的原因，并构成了解读混合静脉血氧张力变化的基础。以混合静脉血氧张力为横坐标、氧消耗率为纵坐标的图表说明了氧通量依赖性氧消耗率。一张图表显示了混合静脉血氧张力与氧输送之间的关系。
动脉血的氧状态包括与动脉血氧张力、血红蛋白氧容量和血红蛋白氧亲和力相关的三组量。其中一组的紊乱可能会被另外一组或两组的相反变化所补偿。氧提取张力表明补偿程度，混合静脉血氧张力是评估氧通量依赖性氧化代谢状态是否存在的关键参数。
