Meldrum J B, Gupta V S, Babiuk L A
Chemotherapy. 1980;26(1):54-63. doi: 10.1159/000237883.
The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. Treatment was initiated either at 4 or 24 h post virus inoculation. The parameter used to evaluate effectiveness was lesion size. Each eye was graded daily for the first 5 days and on alternate days thereafter to day 11. At concentrations of 2 or 5% both MMUdR and Ara-A were found to have potent antikeratitis activity. At 5% concentration, Ara-A provided essentially the same protection against herpes keratitis as 0.1% IUdR, while MMUdR was slightly less effective. The simultaneous application of 2% MMUdR and 2% Ara-A in combination was more effective than 5% MMUdR alone and was effective as 5% Ara-A or 0.1% IUdR in controlling the viral keratitis.
在兔身上研究了5-甲氧基甲基脱氧尿苷（MMUdR）、阿糖腺苷（Ara-A）、5-碘脱氧尿苷（IUdR）以及MMUdR与Ara-A联合用药治疗实验性单纯疱疹性角膜炎的相对疗效。在病毒接种后4小时或24小时开始治疗。用于评估疗效的参数是病变大小。在最初5天每天对每只眼睛进行评分，此后至第11天隔天评分。发现浓度为2%或5%时，MMUdR和Ara-A均具有强大的抗角膜炎活性。在5%浓度时，Ara-A对疱疹性角膜炎的保护作用与0.1% IUdR基本相同，而MMUdR的效果稍差。联合应用2% MMUdR和2% Ara-A比单独使用5% MMUdR更有效，在控制病毒性角膜炎方面与5% Ara-A或0.1% IUdR效果相当。
