9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸酯和9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯对实验性单纯疱疹性角膜炎的作用
Effect of 9-beta-D-arabinofuranosyladenine 5'-monophosphate and 9-beta-D-arabinofuranosylhypoxanthine 5'-monophosphate on experimental herpes simplex keratitis.
作者信息
Kaufman H E, Varnell E D
出版信息
Antimicrob Agents Chemother. 1976 Dec;10(6):885-8. doi: 10.1128/AAC.10.6.885.
Abstract
Treatment of established experimental keratitis caused by herpes simplex virus with 9-beta-d-arabinofuranosyladenine 5'-monophosphate (Ara-AMP) or 9-beta-d-arabinofuranosylhypoxanthine 5'-monophosphate (Ara-HxMP) showed that the Ara-AMP, in a concentration of 2 or 20%, had a significant effect on the keratitis but that 0.4% Ara-HxMP showed only minimal activity. Ara-AMP was also effective in the treatment of idoxuridine-resistant keratitis. No local toxicity with a high concentration (20%) of Ara-AMP was seen, but the duration of therapy was brief.
摘要
用9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸酯（Ara-AMP）或9-β-D-阿拉伯呋喃糖基次黄嘌呤5'-单磷酸酯（Ara-HxMP）治疗由单纯疱疹病毒引起的已确诊实验性角膜炎，结果显示，浓度为2%或20%的Ara-AMP对角膜炎有显著疗效，而0.4%的Ara-HxMP仅显示出最小活性。Ara-AMP在治疗对碘苷耐药的角膜炎方面也有效。未观察到高浓度（20%）的Ara-AMP有局部毒性，但治疗持续时间较短。
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本文引用的文献
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IDU therapy of herpes simplex.单纯疱疹的注射吸毒疗法。 （不过从医学常理看，这个表述不太符合常见医学内容，可能原文有误，正常应该是关于单纯疱疹的某种规范治疗方法表述，比如“Intermittent dosing therapy of herpes simplex”之类，单纯“IDU therapy”这样表述容易误解，这里是按照字面翻译）
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CORNEAL TOXICITY OF CYTOSINE ARABINOSIDE.阿糖胞苷的角膜毒性
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Arch Ophthalmol. 1963 May;69:626-9. doi: 10.1001/archopht.1963.00960040632017.
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Ann N Y Acad Sci. 1965 Jul 30;130(1):168-80. doi: 10.1111/j.1749-6632.1965.tb12550.x.
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