Maxwell V, Shulkes A, Brown J C, Solomon T E, Walsh J H, Grossman M I
Dig Dis Sci. 1980 Feb;25(2):113-6. doi: 10.1007/BF01308308.
Eight male subjects were given pentagastrin by intravenous infusion in doses of 25, 74, 222, 667, and 2000 ng/kg/hr, each dose for 30 min. On another day the same subjects were given the same doses of pentagastrin while gastric inhibitory polypeptide (GIP) was being infused intravenously in a dose of 2 microgram/kg/hr. At the 222 ng/kg/hr dose of pentagastrin, acid output was significantly lower with GIP; at all other doses of pentagastrin, acid output did not differ significantly in tests with and without GIP. Pepsin output in the tests with and without GIP did not differ significantly at any dose of pentagastrin. Plasma concentration of GIP, measured by radioimmunoassay, showed a mean +/- SE plateau level of 7.4 +/- 1.4 ng/ml during GIP infusion and 0.4 +/- 0.1 ng/ml peak level after a standard meal. We conclude that the increase in blood concentration of GIP produced by feeding is probably inadequate to cause significant inhibition of gastric acid or pepsin secretion in man.
八名男性受试者通过静脉输注给予不同剂量的五肽胃泌素，剂量分别为25、74、222、667和2000纳克/千克/小时，每个剂量持续30分钟。在另一天，同样的受试者给予相同剂量的五肽胃泌素，同时以2微克/千克/小时的剂量静脉输注胃抑肽（GIP）。在五肽胃泌素剂量为222纳克/千克/小时时，GIP存在时胃酸分泌显著降低；在五肽胃泌素的所有其他剂量下，有GIP和无GIP的测试中胃酸分泌无显著差异。在任何五肽胃泌素剂量下，有GIP和无GIP测试中的胃蛋白酶分泌均无显著差异。通过放射免疫测定法测得的GIP血浆浓度显示，在GIP输注期间平均±标准误平台水平为7.4±1.4纳克/毫升，标准餐后峰值水平为0.4±0.1纳克/毫升。我们得出结论，进食引起的GIP血浓度升高可能不足以显著抑制人类胃酸或胃蛋白酶分泌。
