Pizza G, Viza D, Fini M, Cuzzocrea D, Menniti D, Corrado F
Eur Urol. 1980;6(1):45-7. doi: 10.1159/000473286.
The presence of tumour-associated antigens in bladder carcinomas has been shown in leucocyte migration inhibition and lymphocyte stimulation using formalin-treated autologous tumour cells as antigen. The treatment of patients with an in vitro produced specific transfer factor enhances their reactivity in these tests. However, when tumour cells from relapses were substituted for those of the primary tumour, the reactivity previously observed was abolished. An antigenic modulation and/or a polymorphic expression of bladder tumour-associated antigens in secondary tumours is suggested and might be responsible for some immunological escapes.
利用经福尔马林处理的自体肿瘤细胞作为抗原，通过白细胞迁移抑制试验和淋巴细胞刺激试验已证实膀胱癌中存在肿瘤相关抗原。用体外产生的特异性转移因子治疗患者可增强他们在这些试验中的反应性。然而，当用复发肿瘤细胞替代原发肿瘤细胞时，先前观察到的反应性就消失了。这提示在继发性肿瘤中存在膀胱肿瘤相关抗原的抗原调制和/或多态性表达，这可能是某些免疫逃逸的原因。
