乙醇对雏鸡颈二腹肌中胆碱、乙酰胆碱、卡巴胆碱和苯基三甲基铵收缩的增强作用。

Ethanol potentiation of choline, acetylcholine, carbachol and phenyltrimethylammonium contractions in the chick biventer cervicis muscle.

作者信息

Clement J G

出版信息

Eur J Pharmacol. 1980 Jan 25;61(2):195-8. doi: 10.1016/0014-2999(80)90165-x.

Abstract

Pretreatment of chick biventer cervicis preparations with ethanol (290 mM) potentiated the EC50 of choline, acetylcholine, carbachol and phenyltrimethylammonium 91%, 319%, 97% and 213%, respectively. Perhaps this interaction of ethanol and neurotransmitter could contribute to the effects on coordination and motor activity produced by ethanol in vivo.

摘要

用乙醇（290 mM）预处理鸡双颈肌标本，可使胆碱、乙酰胆碱、卡巴胆碱和苯基三甲基铵的半数有效浓度（EC50）分别提高91%、319%、97%和213%。乙醇与神经递质之间的这种相互作用可能有助于解释乙醇在体内对协调和运动活动产生的影响。