Grospietsch G, Girndt J, Fenske M, Kuhn W
Geburtshilfe Frauenheilkd. 1980 Jan;40(1):55-64. doi: 10.1055/s-2008-1037022.
During tocolytic treatment with Beta 2-Sympathomimetic drugs pulmonary edema is occasionally observed. The cause remains uncertain. Within 48 hours after the onset of treatment marked water retention is observed. The weight increases, the hemoglobin decreases the hematocrit decreases, the albumin concentration decreases, the water and sodium excretion decreases. The pathogenesis is discussed and recommendations for the management are proposed. Water retention due to tocolytic treatment in addition to the physiologic water retention of pregnancy or in addition to pre-eclampsia cortisone treatment, renal insufficiency, or treatment with intravenous infusions may lead to a hypervolemia which can no longer be compensated by diuresis and therefore can lead to pulmonary edema. A list of 10 groups of patient with a high risk is described. These require thorough observation following tocolytic treatment.
在使用β2-拟交感神经药物进行保胎治疗期间,偶尔会观察到肺水肿。其病因尚不确定。在治疗开始后的48小时内,会观察到明显的水潴留。体重增加,血红蛋白降低,血细胞比容降低,白蛋白浓度降低,水和钠排泄减少。文中讨论了发病机制并提出了管理建议。保胎治疗导致的水潴留,除了孕期生理性水潴留外,或除了子痫前期、皮质醇治疗、肾功能不全或静脉输液治疗外,可能会导致血容量过多,而利尿已无法代偿,进而可能导致肺水肿。文中描述了10组高危患者。这些患者在保胎治疗后需要进行全面观察。