Lee L Y, Djokic T D, Dumont C, Graf P D, Nadel J A
J Appl Physiol Respir Environ Exerc Physiol. 1980 Jan;48(1):163-8. doi: 10.1152/jappl.1980.48.1.163.
In seven studies on three dogs exercising on a treadmill (1.6 km/h), we studied the effect of ozone on ventilatory responses to hypercapnia and to hypoxia. After ozone exposure (0.67 +/- 0.02 ppm by vol; 2 h), the responses of minute volume of ventilation (VE) to progressive hypercapnia and hypoxia were not changed, but the breathing pattern in response to these stimuli changed. We analyzed the breathing pattern by plotting the relationship between VE and tidal volume (VT). During progressive hypercapnia, the slope of VE-VT relationship increased from a control value of 36.1 +/- 1.6 (mean +/- SE) to 93.5 +/- 8.9 min-1 after ozone (n = 7, P less than 0.005); during hypoxia, the slope increased from a control value of 46.1 +/- 8.6 to 142.7 +/- 18.3 min-1 after ozone (n = 6, P less than 0.005). The ozone-induced tachypneic responses to hypercapnia and hypoxia were not affected by inhalation of atropine sulfate or isoproterenol aerosols, but were completely abolished by bilateral vagal blockade. These findings indicate an effect of ozone on the vagal receptors located in the airways and lungs that causes reflex tachypnea during hypercapnia and hypoxia.
在对三只在跑步机上以1.6公里/小时速度运动的狗进行的七项研究中，我们研究了臭氧对高碳酸血症和低氧血症通气反应的影响。臭氧暴露后（体积分数为0.67±0.02 ppm；2小时），每分钟通气量（VE）对渐进性高碳酸血症和低氧血症的反应未发生变化，但对这些刺激的呼吸模式发生了改变。我们通过绘制VE与潮气量（VT）之间的关系来分析呼吸模式。在渐进性高碳酸血症期间，VE-VT关系的斜率从对照值36.1±1.6（平均值±标准误）增加到臭氧暴露后的93.5±8.9分钟-1（n = 7，P<0.005）；在低氧血症期间，斜率从对照值46.1±8.6增加到臭氧暴露后的142.7±18.3分钟-1（n = 6，P<0.005）。臭氧诱导的对高碳酸血症和低氧血症的呼吸急促反应不受吸入硫酸阿托品或异丙肾上腺素气雾剂的影响，但双侧迷走神经阻断可完全消除该反应。这些发现表明臭氧对位于气道和肺部的迷走神经受体有影响，在高碳酸血症和低氧血症期间引起反射性呼吸急促。
