Favier R, Kepenekian G, Desplanches D, Flandrois R
Respir Physiol. 1982 Jan;47(1):107-19. doi: 10.1016/0034-5687(82)90096-2.
The influence of vagal fibres from the lung on ventilatory responses to hypercapnia, hypoxia and exercise was studied in two intact dogs (C) and two chronically lung denervated dogs (C.L.D.). In intact dogs, inspiration duration did not change as tidal volume increased in response to increased chemical drives. Chronic lung denervation did not affect the hypercapnia- or hypoxia-induced elevations in V, despite significant changes in breathing pattern. During exercise, oxygen consumption was similar for C and C.L.D. animals. V for a given oxygen uptake was the same in C and C.L.D. dogs, but VT was higher in C.L.D. animals at all levels of exercise. It is concluded that vagal fibres from the lung play a role in determining the breathing pattern, but are not required for a normal ventilatory response to hypercapnia, hypoxia and exercise. Interaction between vagal sensory input and specific structures sensitive to chemical or physical stimuli is discussed.
在两只完整的狗（C组）和两只慢性肺去神经支配的狗（C.L.D.组）中，研究了来自肺部的迷走神经纤维对高碳酸血症、低氧血症和运动时通气反应的影响。在完整的狗中，随着化学驱动力增加导致潮气量增加时，吸气持续时间没有变化。尽管呼吸模式有显著变化，但慢性肺去神经支配并未影响高碳酸血症或低氧血症诱导的V升高。在运动期间，C组和C.L.D.组动物的耗氧量相似。对于给定的摄氧量，C组和C.L.D.组狗的V相同，但在所有运动水平下，C.L.D.组动物的VT更高。得出的结论是，来自肺部的迷走神经纤维在决定呼吸模式中起作用，但对高碳酸血症、低氧血症和运动的正常通气反应并非必需。讨论了迷走神经感觉输入与对化学或物理刺激敏感的特定结构之间的相互作用。
