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新化合物:芴的衍生物XXXVII:9-取代的3-硝基芴

New compounds: derivatives of fluorene XXXVII: 9-substituted 3-nitrofluorenes.

作者信息

Pan H L, Cole C A, Fletcher T L

出版信息

J Pharm Sci. 1980 Jan;69(1):122-3. doi: 10.1002/jps.2600690141.

Abstract

New 9-substituted 3-nitrofluorenes were prepared as potential intermediates in a study of modified electrophilicity and mutagenicity of the carcinogen 3-N,O-diacetylhydroxylaminofluorene. The reported derivatives, together with some already known 9-substituted 3-nitrofluorenes, were too unstable to survive the reducing conditions required to transform the nitro group to the corresponding hydroxylamine.

摘要

新型9-取代的3-硝基芴被制备出来,作为研究致癌物3-N,O-二乙酰羟基氨基芴的修饰亲电性和诱变性的潜在中间体。所报道的衍生物,连同一些已知的9-取代的3-硝基芴,都过于不稳定,无法在将硝基转化为相应羟胺所需的还原条件下存活。

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