Pan H L, Cole C A, Fletcher T L
J Pharm Sci. 1980 Jan;69(1):122-3. doi: 10.1002/jps.2600690141.
New 9-substituted 3-nitrofluorenes were prepared as potential intermediates in a study of modified electrophilicity and mutagenicity of the carcinogen 3-N,O-diacetylhydroxylaminofluorene. The reported derivatives, together with some already known 9-substituted 3-nitrofluorenes, were too unstable to survive the reducing conditions required to transform the nitro group to the corresponding hydroxylamine.
新型9-取代的3-硝基芴被制备出来,作为研究致癌物3-N,O-二乙酰羟基氨基芴的修饰亲电性和诱变性的潜在中间体。所报道的衍生物,连同一些已知的9-取代的3-硝基芴,都过于不稳定,无法在将硝基转化为相应羟胺所需的还原条件下存活。