依托红霉素和氯丙嗪对不同年龄大鼠分离肝细胞的细胞毒性作用：简要报告

Cytotoxic effects of erythromycin estolate and chlorpromazine on hepatocytes isolated from rats of varying ages: a brief note.

作者信息

Abernathy C O, Lukacs L, Zimmerman H J

出版信息

Mech Ageing Dev. 1980 Jan;12(1):1-6. doi: 10.1016/0047-6374(80)90022-6.

Abstract

Hepatocytes isolated from young (1 month) rats were as sensitive to the cytotoxic effects of erythromycin estolate and chlorpromazine as were liver cells obtained from older (3, 10 and 24 months) rats. The hepatocytes from the 24-month-old rats released aspartate transaminase more slowly than did parenchymal cells isolated from the younger rats.

摘要

从年轻（1个月）大鼠分离出的肝细胞对无味红霉素和氯丙嗪的细胞毒性作用的敏感性与从年长（3、10和24个月）大鼠获得的肝细胞相同。24个月大的大鼠的肝细胞释放天冬氨酸转氨酶的速度比从年轻大鼠分离出的实质细胞慢。