Canessa M, Adragna N, Solomon H S, Connolly T M, Tosteson D C
N Engl J Med. 1980 Apr 3;302(14):772-6. doi: 10.1056/NEJM198004033021403.
This paper describes experiments showing that one of the pathways of sodium transport across the red-cell membrane, sodium-lithium countertransport, is faster in patients with essential hypertension than in control subjects. This transport system accepts only sodium or lithium and is not inhibited by ouabain. The maximum rate of transport shows inherited differences. The mean maximum rate of sodium-lithium countertransport was found to be 0.55 +/- 0.02 (mean +/- S.E.M.) mmol (liter of red cells X hour)(-1) in a group of 36 patients with essential hypertension and 0.24 +/- 0.02 in 26 control subjects (P less than 0.001). The first-degree relatives of eight patients with essential hypertension and 10 control subjects had mean maximum rates of sodium-lithium countertransport of 0.54 +/- 0.05 and 0.23 +/- 0.02, respectively. Five patients with secondary hypertension had normal mean maximum rates of sodium-lithium countertransport. The relation between heritability of red-cell sodium-lithium countertransport and essential hypertension should be investigated further.
本文描述的实验表明，钠通过红细胞膜转运的途径之一——钠-锂逆向转运，在原发性高血压患者中比在对照受试者中更快。该转运系统只接受钠或锂，不受哇巴因抑制。转运的最大速率存在遗传差异。在一组36例原发性高血压患者中，钠-锂逆向转运的平均最大速率为0.55±0.02（均值±标准误）mmol/（升红细胞×小时），而在26例对照受试者中为0.24±0.02（P<0.001）。8例原发性高血压患者和10例对照受试者的一级亲属中，钠-锂逆向转运的平均最大速率分别为0.54±0.05和0.23±0.02。5例继发性高血压患者的钠-锂逆向转运平均最大速率正常。红细胞钠-锂逆向转运的遗传性与原发性高血压之间的关系应进一步研究。
