Spradling-Reeves Kimberly D, Shade Robert E, Haywood Joseph R, Cox Laura A
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
J Am Soc Hypertens. 2017 Mar;11(3):178-184. doi: 10.1016/j.jash.2017.01.010. Epub 2017 Feb 3.
An increased level of sodium-lithium countertransport (SLC) activity has been associated with salt-sensitive hypertension. Previous findings have suggested that dysregulation of the renin-angiotensin-aldosterone system (RAAS) may be involved in the mechanism linking elevated SLC activity and hypertension. Therefore, baboons with different levels of SLC activity were given two diets differing in sodium content, with and without an angiotensin II (ANG II) infusion, to investigate the relationship between SLC activity, the RAAS, and physiological regulation by sodium. Although we anticipated that high SLC activity would be associated with inappropriate function of the RAAS and greater arterial pressure sensitivity to dietary sodium and ANG II and that low SLC activity would be associated with the least BP sensitivity, we found that the low SLC phenotype correlated with BP sensitivity similar to the high SLC phenotype, and the normal SLC phenotype showed the least BP sensitivity to dietary sodium and ANG II.
钠-锂逆向转运（SLC）活性水平升高与盐敏感性高血压有关。先前的研究结果表明，肾素-血管紧张素-醛固酮系统（RAAS）失调可能参与了将升高的SLC活性与高血压联系起来的机制。因此，给予具有不同SLC活性水平的狒狒两种钠含量不同的饮食，并分别进行有无血管紧张素II（ANG II）输注，以研究SLC活性、RAAS和钠的生理调节之间的关系。尽管我们预期高SLC活性会与RAAS功能异常以及动脉血压对饮食钠和ANG II的敏感性增加有关，而低SLC活性会与最低的血压敏感性有关，但我们发现低SLC表型与血压敏感性的相关性与高SLC表型相似，而正常SLC表型对饮食钠和ANG II的血压敏感性最低。
