连通细胞间连接的结构。

Structure of the junction between communicating cells.

作者信息

Unwin P N, Zampighi G

出版信息

Nature. 1980 Feb 7;283(5747):545-9. doi: 10.1038/283545a0.

Abstract

An 18-A resolution map of the 'gap junction' has been obtained by electron microscopy. The protein oligomer in the junctional membranes, the 'connexon', is a cyclinder composed of six subunits which are titled around its axis. Analysis of two different subunit configurations suggests how the connexon might regulate the passage of small molecules between cell interiors.

摘要

通过电子显微镜已获得“间隙连接”的18埃分辨率图谱。连接膜中的蛋白质寡聚体“连接子”是一个由六个亚基组成的圆柱体，这些亚基围绕其轴倾斜。对两种不同亚基构型的分析表明连接子可能如何调节小分子在细胞内部之间的通过。