Schwarz K B, Goldstein P D, Witztum J L, Schonfeld G
Pediatrics. 1980 Feb;65(2):243-50.
In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of colestipol therapy plus diet serum vitamin A and E concentrations did decrease in the five patients with good drug adherence (vitamin A, 68 +/- 11 vs 35 +/- 4 microgram/100 ml, P less than .005) (vitamin E, 14 +/- 1 vs 11 +/- 1 microgram/ml, P less than .05). However, those concentrations remained within normal limits. (4) Colestipol therapy plus diet had no effect on prothrombin time, serum 25-hydroxycholecalciferol, folate, or calcium metabolism (as studied by sequential determination of serum total and ionized calcium phosphorus, alkaline phosphatase, and parathyroid hormone).
(1)考来替泊疗法加饮食控制使11名高胆固醇血症儿童在两个月后总胆固醇降低了19±3%，5名儿童在两年后降低了13±5%。(2)饮食疗法并未显著降低任何一种脂溶性维生素或叶酸的血清浓度。(3)在接受考来替泊疗法加饮食控制的24个月期间，5名药物依从性良好的患者血清维生素A和E浓度确实有所下降(维生素A，68±11对35±4微克/100毫升，P<0.005)(维生素E，14±1对11±1微克/毫升，P<0.05)。然而，这些浓度仍在正常范围内。(4)考来替泊疗法加饮食控制对凝血酶原时间、血清25-羟胆钙化醇、叶酸或钙代谢没有影响(通过连续测定血清总钙和离子钙、磷、碱性磷酸酶和甲状旁腺激素来研究)。
