• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Loopstructures in synthetic oligodeoxynucleotides.合成寡脱氧核苷酸中的环结构。
Nucleic Acids Res. 1980 Jan 11;8(1):169-81. doi: 10.1093/nar/8.1.169.
2
Perturbation of DNA hairpins containing the EcoRI recognition site by hairpin loops of varying size and composition: physical (NMR and UV) and enzymatic (EcoRI) studies.不同大小和组成的发夹环对含有EcoRI识别位点的DNA发夹的扰动：物理（核磁共振和紫外）及酶学（EcoRI）研究
Nucleic Acids Res. 1990 Mar 25;18(6):1489-98. doi: 10.1093/nar/18.6.1489.
3
Local destabilisation of a DNA double helix by a T--T wobble pair.T-T摆动配对导致DNA双螺旋局部不稳定。
Nature. 1979 Sep 20;281(5728):235-6. doi: 10.1038/281235a0.
4
Influence of loop residues on the relative stabilities of DNA hairpin structures.环区残基对DNA发夹结构相对稳定性的影响。
Proc Natl Acad Sci U S A. 1988 Sep;85(17):6242-6. doi: 10.1073/pnas.85.17.6242.
5
Effects of base sequence on the loop folding in DNA hairpins.碱基序列对DNA发夹中环折叠的影响。
Biochemistry. 1989 Sep 5;28(18):7491-8. doi: 10.1021/bi00444a049.
6
Comparative study of ribonucleotide, deoxyribonucleotide, and hybrid oligonucleotide helices by nuclear magnetic resonance.通过核磁共振对核糖核苷酸、脱氧核糖核苷酸和杂交寡核苷酸螺旋进行的比较研究。
Biochemistry. 1981 Jul 7;20(14):3986-96. doi: 10.1021/bi00517a007.
7
Structural features of the DNA hairpin d(ATCCTA-GTTA-TAGGAT): formation of a G-A base pair in the loop.DNA发夹d(ATCCTA - GTTA - TAGGAT)的结构特征：环中形成G - A碱基对
Nucleic Acids Res. 1997 Apr 15;25(8):1537-47. doi: 10.1093/nar/25.8.1537.
8
Hairpin formation in synthetic oligonucleotides.合成寡核苷酸中的发夹结构形成。
Biochimie. 1985 Jul-Aug;67(7-8):685-95. doi: 10.1016/s0300-9084(85)80156-5.
9
Hairpin structures in synthetic oligodeoxynucleotides: sequence effects on the duplex-to-hairpin transition.合成寡脱氧核苷酸中的发夹结构：序列对双链到发夹转变的影响。
Biochimie. 1989 Jul;71(7):793-803. doi: 10.1016/0300-9084(89)90042-4.
10
Occurrence, solution structure and stability of DNA hairpins stabilized by a GA/CG helix unit.由GA/CG螺旋单元稳定的DNA发夹的出现、溶液结构及稳定性
Nucleic Acids Res. 1995 Nov 25;23(22):4717-25. doi: 10.1093/nar/23.22.4717.

引用本文的文献

1
Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus.嗜热古菌 Sulfolobus solfataricus 异源二聚体引物通过不连续模板进行模板依赖性聚合。
Nucleic Acids Res. 2012 Apr;40(8):3470-83. doi: 10.1093/nar/gkr1256. Epub 2011 Dec 20.
2
The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study.铁蛋白mRNA中铁反应元件（IRE）发夹环中单个G对结构的重要性：一项核磁共振光谱研究。
Nucleic Acids Res. 1995 Jan 11;23(1):146-53. doi: 10.1093/nar/23.1.146.
3
Atypical base composition of foldback DNA.回文DNA的非典型碱基组成。
Experientia. 1982 Mar 15;38(3):344-6. doi: 10.1007/BF01949382.
4
Nuclear magnetic resonance studies on yeast tRNAPhe I. Assignment of the iminoproton resonances of the acceptor and D stem by means of Nuclear Overhauser Effect experiments at 500 MHz.酵母苯丙氨酸转运核糖核酸的核磁共振研究 I. 通过500兆赫的核Overhauser效应实验对受体和D茎的亚氨基质子共振进行归属
Nucleic Acids Res. 1982 Nov 11;10(21):6981-7000. doi: 10.1093/nar/10.21.6981.
5
Proton NMR study and conformational analysis of d(CGT), d(TCG) and d(CGTCG) in aqueous solution. The effect of a dangling thymidine and of a thymidine mismatch on DNA mini-duplexes.水溶液中d(CGT)、d(TCG)和d(CGTCG)的质子核磁共振研究与构象分析。游离胸苷和胸苷错配对DNA小双链体的影响。
Nucleic Acids Res. 1984 Jun 25;12(12):5061-78. doi: 10.1093/nar/12.12.5061.
6
Nuclear magnetic resonance studies on yeast tRNAPhe. II. Assignment of the iminoproton resonances of the anticodon and T stem by means of nuclear Overhauser effect experiments at 500 MHz.酵母苯丙氨酸转运核糖核酸的核磁共振研究。II. 通过500兆赫的核Overhauser效应实验对反密码子和T茎的亚氨基质子共振进行归属。
Nucleic Acids Res. 1983 Jul 11;11(13):4483-99. doi: 10.1093/nar/11.13.4483.
7
Primary and secondary structure specificity of the cleavage of 'single-stranded' DNA by endonuclease Hinf I.内切核酸酶Hinf I切割“单链”DNA的一级和二级结构特异性
Nucleic Acids Res. 1982 May 11;10(9):2763-73. doi: 10.1093/nar/10.9.2763.
8
Preparation and melting of single strand circular DNA loops.单链环状DNA环的制备与解链
Nucleic Acids Res. 1985 Dec 9;13(23):8611-21. doi: 10.1093/nar/13.23.8611.
9
Nuclear magnetic resonance and circular dichroism studies of a duplex--single-stranded hairpin loop equilibrium for the oligodeoxyribonucleotide sequence d(CGCGATTCGCG).对寡脱氧核糖核苷酸序列d（CGCGATTCGCG）的双链-单链发夹环平衡进行的核磁共振和圆二色性研究。
Nucleic Acids Res. 1985 Sep 11;13(17):6375-86. doi: 10.1093/nar/13.17.6375.
10
Duplex-hairpin transitions in DNA: NMR studies on CGCGTATACGCG.DNA中的双链-发夹转变：关于CGCGTATACGCG的核磁共振研究
Nucleic Acids Res. 1985 May 24;13(10):3755-72. doi: 10.1093/nar/13.10.3755.

本文引用的文献

1
Estimation of secondary structure in ribonucleic acids.核糖核酸二级结构的估算
Nature. 1971 Apr 9;230(5293):362-7. doi: 10.1038/230362a0.
2
Free energy of imperfect nucleic acid helices. 3. Small internal loops resulting from mismatches.不完全核酸螺旋的自由能。3. 错配导致的小内部环。
J Mol Biol. 1973 Aug 5;78(2):301-19. doi: 10.1016/0022-2836(73)90118-6.
3
Conformational analysis of the sugar ring in nucleosides and nucleotides. Improved method for the interpretation of proton magnetic resonance coupling constants.核苷和核苷酸中糖环的构象分析。解释质子磁共振耦合常数的改进方法。
J Am Chem Soc. 1973 Apr 4;95(7):2333-44. doi: 10.1021/ja00788a038.
4
Improved estimation of secondary structure in ribonucleic acids.核糖核酸二级结构的改进估计。
Nat New Biol. 1973 Nov 14;246(150):40-1. doi: 10.1038/newbio246040a0.
5
Conformation and interaction of short nucleic acid double-stranded helices. I. Proton magnetic resonance studies on the nonexchangeable protons of ribosyl ApApGpCpUpU.短核酸双链螺旋的构象与相互作用。I. 核糖基ApApGpCpUpU不可交换质子的质子磁共振研究。
Biochemistry. 1975 Nov 4;14(22):4847-63. doi: 10.1021/bi00693a012.
6
Conformational analysis of a DNA triplet in aqueous solution. Thymidylyl-(3'-5')-thymidylyl-(3'-5')-2'-deoxyadenosine, d(T-T-A), studied by 1H nuclear magnetic resonance at 360 MHz.水溶液中DNA三联体的构象分析。通过360兆赫兹的1H核磁共振研究胸苷酰基-(3'-5')-胸苷酰基-(3'-5')-2'-脱氧腺苷，即d(T-T-A)。
Eur J Biochem. 1976 Dec 11;71(2):557-62. doi: 10.1111/j.1432-1033.1976.tb11145.x.
7
Ring current shielding effects in nucleic acid double helices.核酸双螺旋中的环电流屏蔽效应。
Nucleic Acids Res. 1976 Jun;3(6):1437-47. doi: 10.1093/nar/3.6.1437.
8
On the atomic or "local" contributions to proton chemical shifts due to the anisotropy of the diamagnetic susceptibility of the nucleic acid base.
Biochem Biophys Res Commun. 1976 May 17;70(2):578-81. doi: 10.1016/0006-291x(76)91086-x.
9
Local destabilisation of a DNA double helix by a T--T wobble pair.T-T摆动配对导致DNA双螺旋局部不稳定。
Nature. 1979 Sep 20;281(5728):235-6. doi: 10.1038/281235a0.
10
Proton nuclear magnetic resonance investigations of fraying in double-stranded d-ApTpGpCpApT in H2O solution.在H2O溶液中双链d - ApTpGpCpApT磨损情况的质子核磁共振研究。
Biochemistry. 1975 Jun 17;14(12):2651-6. doi: 10.1021/bi00683a014.

合成寡脱氧核苷酸中的环结构。

Loopstructures in synthetic oligodeoxynucleotides.

作者信息

Haasnoot C A, den Hartog J H, de Rooij J F, van Boom J H, Altona C

出版信息

Nucleic Acids Res. 1980 Jan 11;8(1):169-81. doi: 10.1093/nar/8.1.169.

DOI:10.1093/nar/8.1.169
PMID:7355127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC327250/
Abstract

A comparative nuclear magnetic resonance study of the hydrogen-bonded imino protons in a series of synthetic DNA fragments is presented. The fragments ATCCTA(Tn)TAGGAT are in principle capable of forming either a self-complementary hairpin loop structure (monomer form) or an interior loop structure (dimeric form). It has been shown, that for n = 1 only the dimer structure is present in aqueous solution, whereas the exclusive existence of the hairpin loop structure is indicated for n = 3, 4 & 5. Surprisingly, for n = 2 two different structures appear to be present in solution. Concentration studies show that both monomers and dimers exist side by side in this case. Hairpins as well as interior loops form extra "melting sites" in addition to the wellknown fraying phenomenon at the terminus of the double helix.

摘要

本文介绍了一系列合成DNA片段中氢键亚氨基质子的比较核磁共振研究。片段ATCCTA(Tn)TAGGAT原则上能够形成自互补发夹环结构（单体形式）或内环结构（二聚体形式）。研究表明，当n = 1时，水溶液中仅存在二聚体结构，而当n = 3、4和5时，则表明仅存在发夹环结构。令人惊讶的是，当n = 2时，溶液中似乎存在两种不同的结构。浓度研究表明，在这种情况下，单体和二聚体并存。除了双螺旋末端众所周知的解链现象外，发夹环和内环还形成了额外的“解链位点”。