Gittes R F
Urol Clin North Am. 1986 May;13(2):201-5.
Both clinical and experimental observations establish that an adenocarcinoma of the colon is likely to occur at the suture line of ureterosigmoidostomy. The carcinogenesis depends on the initial presence of urine, feces, urothelium, and colonic epithelium in close apposition at a healing suture line. It does not occur in isolated colon loops used for urinary diversion. In our rat model, tumors were completely prevented by interposing ileum between the urothelium and colon. Clinical prevention requires that accurate hospital registries of patients at risk be established and that repeated annual colonoscopy be carried out on all of them.
临床和实验观察均证实，输尿管乙状结肠吻合术的缝合线处很可能发生结肠腺癌。致癌作用取决于在愈合的缝合线处尿液、粪便、尿路上皮和结肠上皮紧密相邻的初始状态。它不会发生在用于尿流改道的孤立结肠袢中。在我们的大鼠模型中，通过在尿路上皮和结肠之间插入回肠可完全预防肿瘤。临床预防需要建立准确的高危患者医院登记系统，并对所有患者每年进行重复结肠镜检查。
